The product was originally conceived by its developer Dr. Alexander Riftine.
Between 1981 and 1982 the first trial version of the product was developed based on the Time Domain and Auto-regression Function approach. By 1982 it became clear that the Time Domain approach was fundamentally flawed as it didn't reflect the internal structure of the heart rhythm. It was also revealed that the probability of erroneous assessments was no less than 30%, which was unacceptable.
In 1982 a new trial version was developed based on the Frequency Domain approach.
In 1982 a massive data collection effort was started, and by the summer of 1986 12000 samples of Orthostatic test data and 700 samples of Stress test data were collected and analyzed. One of the results of this analysis was a proprietary Classification of the Transitional Periods during the Orthostatic test, developed in 1986.
To provide a meaningful and systematic interpretation for his entire collection of data, Dr. Riftine started searching for a fundamentally new methodology that would be more comprehensive and precise in measuring the individual's current physical/physiological state as well as a health resource and genetic ability.
In the first part of 1987, Dr. Riftine formulated a novel theory for the quantitative assessment of the individual's functional state utilizing HRV methodology. This theory was based on Dr. Riftine's original ideas in the field of Bio-medical Cybernetics and Normal Physiology. The practical applications of the theory - specifically, its proprietary algorithms for the quantitative assessment of the individual's functional state - were developed on the theoretical basis of Marvin Minsky's Frame Theory.
The first product based on Dr. Riftine's new theory, Health-Express, was developed by 1988. It provided an assessment of the level of Physical Fitness. The marketing campaign for Health-Express was launched in 1988.
In 1992 a new product, Nerve-Express(former name of the Intellewave), was launched. Nerve-Express is the first product to provide an automatic quantitative assessment of the Autonomic Nervous System(ANS).
In the past, the division line (between PNS and SNS) was found at a mean Frequency of 0.15 Hz (for an average healthy person). However, for each individual, this transition point varies.
Nerve-Express was able to come up with a calculation which is unique to any given person.
In addition, Nerve-Express also dealt with the problem of reducing all possible variations of multiple parameters (20-30) into a quantitative relationship between only two parameters: SNS and PSNS.
Nerve-Express is the first and only system to solve this problem of SNS-PSNS quantification. This technological breakthrough is achieved by the application of Dr. Riftine's proprietary algorithms.
The original and all subsequent releases of Nerve-Express include Health-Express.
From 1997 to 2000 a validation study of Nerve-Express was conducted by J. Thomas Bigger, Jr., M.D., Head of Research Holter Laboratory, at Columbia University College of Physicians and Surgeons.
In 1998 a "real-time" (up to 48 hours) Autonomic assessment was added to Nerve-Express.
In May 2001 the European registration (CE mark) for Nerve-Express was granted and in August 2001 Nerve-Express was launched on the European market.
In 2003 another test was added - the Valsalva maneuver combined with Deep Breathing.
2004 it becomes compatible with ambulatory Holter-Monitor for 24 hours Autonomic assessment
with the possibility to see on one-page difference between "sleep" time and
At October , 2006 Intellewave HRV 1.0 system was granted FDA 510K clearance.
2008 it becomes compatible with PBI PC ECG device which enable to see one lead ECG on the screen and printout afterwords any part of ECG.
2010 Patent "Quantitative assessment of Autonomic function based on Heart Rate Variability" is granted.
2011 Corscience, GMBx ECG wireless Bluetooth device added to the list of devices.
2019 Meditech ABPM-05 Blood pressure full automatic device was added to the list of devices.
2021 New test was added - Real-Time Autonomic monitor during Tilt-Table testing.